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Taking Orenitram
Adjustable dosing Treatment goals Additional considerations

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Taking Orenitram

Orenitram is available in 5 different dose strengths:

Orenitram® (treprostinil) Dosage Options – 0.125 mg, 0.25 mg, 1 mg, 2.5 mg, 5 mg Orenitram® (treprostinil) Dosage Options – 0.125 mg, 0.25 mg, 1 mg, 2.5 mg, 5mg

Five different dose strengths, and the option for either twice-daily or 3-times-daily dosing, allow your doctor more flexibility in finding the exact dose combination that is right for you.

Your dose will be adjusted over time. This will be based on what works best for your PAH symptoms and how you tolerate taking Orenitram.

Orenitram should be taken with food.

Take Orenitram exactly as prescribed by your healthcare provider. If you miss a dose of Orenitram, take the dose as soon as possible with food. If you miss 2 or more doses, call your healthcare provider for instructions.

Setting your treatment goals

Setting goals is an important part of your treatment. Your healthcare provider can help you figure out what goals are appropriate for you. They may be related to your daily life or to your ability to enjoy activities with loved ones. Keep track of how you feel after taking your medication, as well as what combination of foods you took along with your medication. Use these notes to discuss how you are feeling with your healthcare provider.

Setting your treatment goals

Setting goals is an important part of your treatment. Your healthcare provider can help you figure out what goals are appropriate for you. They may be related to your daily life or to your ability to enjoy activities with loved ones. Keep track of how you feel after taking your medication, as well as what combination of foods you took along with your medication. Use these notes to discuss how you are feeling with your healthcare provider.

Daily Treatment Diary

Use the Treatment Diary to record your daily Orenitram routine, and share your notes with your healthcare team so they can help guide your treatment.

Download Now

Some important things to remember

Orenitram® (treprostinil) Additional Considerations Orenitram® (treprostinil) Additional Considerations

For additional information, please see Patient Information for Orenitram.

Do not take Orenitram if you have severe liver problems.

Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider. Stopping Orenitram suddenly may cause your PAH symptoms to worsen.

You may see the tablet shell in your stools (bowel movements). This is normal. The tablet shell is not digested. If you have diverticulosis, Orenitram tablets can lodge in a diverticulum in your intestine.

Next: Resources and support to help you with your treatment

Important Safety Information for Orenitram

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

How should I take Orenitram?

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider. Please see Full Prescribing Information and Patient Information at www.orenitram.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).

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IMPORTANT SAFETY INFORMATION FOR ORENITRAM

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Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

  • If you have liver problems or diverticulosis.
  • If you are pregnant, breastfeeding, and/or plan to become pregnant or breastfeed. It is not known if Orenitram will harm your unborn baby or if Orenitram passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Orenitram.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains treprostinil, such as Remodulin® or Tyvaso®.

How should I take Orenitram?

  • Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • Orenitram is usually taken 3 times a day (about every 8 hours) or 2 times a day (about every 12 hours). Your healthcare provider will tell you how often you should take Orenitram. If you have side effects, your healthcare provider may tell you to change your dose or when you take Orenitram. Take Orenitram with food.
  • Swallow Orenitram tablets whole. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects.
  • If you miss your dose of Orenitram, take the missed dose as soon as possible with food.
  • If you miss 2 or more doses of Orenitram, call your healthcare provider to see if you need to change your dose.
  • If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.
  • You may see the tablet shell in your stools (bowel movements). This is usually normal. The tablet shell is not digested. If you have diverticulosis, the tablet shell may get stuck in a blind pouch or diverticulum in your intestine.

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

  • Stopping Orenitram suddenly may cause worsening of your PAH symptoms. Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • The most common side effects of Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in arms, legs, and jaw. These are not all of the possible side effects of Orenitram. Tell your healthcare provider if you have any side effect that bothers you or does not go away.
  • Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider. Please see Full Prescribing Information and Patient Information at www.orenitram.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).

OREISIconOCT19