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What is PAH?
What is PAH? PAH symptoms How is PAH diagnosed? Why is it important to treat PAH? What is prostacyclin?

PAH can impact your everyday activities

What is pulmonary arterial hypertension?

Pulmonary arterial hypertension (PAH) is high blood pressure in the arteries of the lungs (called pulmonary arteries). Pulmonary arteries carry blood from the heart into the lungs, where it picks up oxygen for delivery to the rest of the body.

Healthy Blood Vessel vs. Blood Vessel with PAH Healthy Blood Vessel vs. Blood Vessel with PAH

The effects of PAH can make it difficult to perform certain daily activities, such as walking.

People with PAH may experience

PAH is a progressive disease

PAH worsens over time and can lead to serious complications. The physical symptoms you experience may not always reflect whether PAH is progressing or how it is affecting your heart. If you believe you have PAH, it's important to talk to your healthcare provider as early as possible so it can be determined if you have PAH and whether or not you need to begin treatment.

Your healthcare provider may perform some tests to initially diagnose your PAH

6-minute walk distance (6MWD)
Tracks how far you can walk in 6 minutes.

Echocardiogram
Uses sound waves to see how well your heart is beating and pumping blood.

Pulmonary function tests
Measure how well your lungs work.

Chest x-ray
Shows if your pulmonary arteries and right ventricle are enlarged.

Ventilation/Perfusion scan (V/Q lung scan)
Measures breathing and circulation in all areas of your lungs.

Blood tests
Rule out other diseases that may be causing your symptoms.

If PAH is suspected, a right heart catheterization may be performed to confirm the diagnosis

Right heart catheterization measures the pressure in your pulmonary arteries and shows how well your heart is pumping blood to the rest of your body.

Prostacyclin analogues are an FDA-approved treatment for PAH

In a person with PAH, the body produces low levels of prostacyclin. Prostacyclin is a natural substance that helps keep arteries in the lungs open and working properly. When the body does not produce enough prostacyclin, the pulmonary arteries become narrow. This causes the heart to have to work harder to do its job.

Prostacyclin analogues mimic the effects of the natural prostacyclin found in the body. Treatment with a prostacyclin analogue may make it easier for your heart to pump blood through your lungs. This can help improve your ability to exercise.

Experts have supported the use of prostacyclin-class therapy for over a decade.

Prostacyclin therapies can be taken 3 different ways

Next: Orenitram is the only FDA-approved oral prostacyclin analogue in a tablet

Important Safety Information for Orenitram

Do not take Orenitram if you have severe liver problems.

Before you take Orenitram, tell your healthcare provider if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start or stop any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains the same ingredient, treprostinil. Know the medicines you take. Keep a list of them and the dose you take to show to your healthcare provider and pharmacist when you get a new medicine.

Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider. Stopping Orenitram suddenly may cause worsening of your PAH symptoms. If you miss two or more doses of Orenitram, call your healthcare provider. If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.

If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. Take Orenitram with food.

Orenitram can cause serious side effects, including an increased risk of bleeding. This risk could be increased if you are taking blood thinners such as warfarin.

The most common side effects of Orenitram include headache, diarrhea, nausea and flushing. These are not all of the possible side effects of Orenitram. Tell your doctor about any side effects that bother you, get worse over time, or do not go away.

Indication

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram may improve your ability to exercise. It is not known if Orenitram is safe and effective in children under 18 years of age.

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Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

Please see Full Prescribing Information and Patient Information for Orenitram.

For additional information about Orenitram, call 1-877-UNITHER (1-877-864-8437).

This information is provided for educational purposes only and is not intended as treatment advice. Consult your healthcare provider for treatment advice.

IMPORTANT SAFETY INFORMATION FOR ORENITRAM

Expand

Do not take Orenitram if you have severe liver problems.

Before you take Orenitram, tell your healthcare provider if you:

  • Have liver problems, diverticulosis, or any other medical conditions
  • Are pregnant, breastfeeding, and/or plan to become pregnant or breastfeed. It is not known if Orenitram will harm your unborn baby or if Orenitram passes into your breast milk. You and your healthcare provider should decide if you will take Orenitram or breastfeed. You should not do both

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start or stop any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains the same ingredient, treprostinil. Know the medicines you take. Keep a list of them and the dose you take to show to your healthcare provider and pharmacist when you get a new medicine.

Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider. Stopping Orenitram suddenly may cause worsening of your PAH symptoms. If you miss two or more doses of Orenitram, call your healthcare provider. If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.

If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. Take Orenitram with food.

Orenitram can cause serious side effects, including an increased risk of bleeding. This risk could be increased if you are taking blood thinners such as warfarin.

The most common side effects of Orenitram include headache, diarrhea, nausea and flushing. These are not all of the possible side effects of Orenitram. Tell your doctor about any side effects that bother you, get worse over time, or do not go away.

Indication

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram may improve your ability to exercise. It is not known if Orenitram is safe and effective in children under 18 years of age.

OREISIdtcJAN16

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

Please see Full Prescribing Information and Patient Information for Orenitram.

For additional information about Orenitram, call 1-877-UNITHER (1-877-864-8437).

This information is provided for educational purposes only and is not intended as treatment advice. Consult your healthcare provider for treatment advice.