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PAH Treatment
What is Orenitram? Oral delivery Side effects Patient Support Program

Open up possibilities with Orenitram

What is Orenitram?

Orenitram is the only FDA-approved prostacyclin analogue in a tablet to treat PAH and has been shown to improve exercise ability (or walking distance). In a large study, patients on Orenitram showed improvement in their 6 minute walk distance compared to patients on placebo (a pill without active ingredients).* With Orenitram, there is information available for your healthcare team about how patients stable on pump therapy (treprostinil) transitioned to oral therapy. It is not known if Orenitram is safe and effective in children under 18 years of age.

*A 12 week study of 349 patients with PAH not currently receiving any other PAH therapy

Similar medicine as in a pump, but in a tablet

Orenitram is the only pill that gives you the same type of medicine (active ingredient) that is available in pump therapy. In a small study, patients in the hospital stable on pump therapy (treprostinil) successfully switched to Orenitram while maintaining their 6-minute walk distance and right heart catheterization results.

An open-label, uncontrolled (no placebo) study of 33 hospitalized patients with PAH.

Orenitram may help you reach your goals

Because Orenitram is an oral option, you may enjoy activities like being in the pool or taking a bath. Taking Orenitram may improve your ability to exercise. This means you could see improvement in physical activities, such as walking to the mailbox.

If you have been diagnosed recently or have had PAH for some time, Orenitram may be right for you.

Doctor Discussion Guide

The Doctor Discussion Guide provides questions and discussion topics to help guide the conversation with your healthcare provider to determine if Orenitram may fit into your treatment plan.

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How does Orenitram work?

If you have PAH, your body may not produce enough of a natural substance called prostacyclin. Orenitram mimics some of the effects of the natural prostacyclin that your body lacks. This can help open up blood vessels, making it easier for your heart to pump blood through your lungs.

Dosing that fits your schedule

Your doctor will prescribe Orenitram to be taken either twice or 3 times each day. With 4 different dose strengths available, your healthcare provider is able to prescribe Orenitram according to your treatment needs. Learn more about taking Orenitram.

You may experience side effects when taking Orenitram

Some of the most common side effects experienced by people taking Orenitram include

 Headache        Nausea        Diarrhea       Flushing     

There are other possible side effects of Orenitram. Tell your healthcare provider about any side effects that bother you, get worse over time, or do not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

Daily Treatment Diary

The Daily Treatment Diary can help you keep track of how you are feeling each day of treatment. You can also write down important notes that you may want to discuss with your healthcare provider.

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Support during your treatment

In addition to support from your healthcare provider, Orenitram patients can receive support from Specialty Pharmacies and may be eligible for various programs offered by United Therapeutics, the company that makes Orenitram.

PEER Network Mentors

Orenitram Support
Is Available

Explore support available, from in-home training to telephone support, as well as educational resources or connecting with a PEER Mentor.

Learn More

Next: How to take Orenitram

Important Safety Information for Orenitram

Do not take Orenitram if you have severe liver problems.

Before you take Orenitram, tell your healthcare provider if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start or stop any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains the same ingredient, treprostinil. Know the medicines you take. Keep a list of them and the dose you take to show to your healthcare provider and pharmacist when you get a new medicine.

Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider. Stopping Orenitram suddenly may cause worsening of your PAH symptoms. If you miss two or more doses of Orenitram, call your healthcare provider. If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.

If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. Take Orenitram with food.

Orenitram can cause serious side effects, including an increased risk of bleeding. This risk could be increased if you are taking blood thinners such as warfarin.

The most common side effects of Orenitram include headache, diarrhea, nausea and flushing. These are not all of the possible side effects of Orenitram. Tell your doctor about any side effects that bother you, get worse over time, or do not go away.

Indication

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram may improve your ability to exercise. It is not known if Orenitram is safe and effective in children under 18 years of age.

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Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

Please see Full Prescribing Information and Patient Information for Orenitram.

For additional information about Orenitram, call 1-877-UNITHER (1-877-864-8437).

This information is provided for educational purposes only and is not intended as treatment advice. Consult your healthcare provider for treatment advice.

IMPORTANT SAFETY INFORMATION FOR ORENITRAM

Expand

Do not take Orenitram if you have severe liver problems.

Before you take Orenitram, tell your healthcare provider if you:

  • Have liver problems, diverticulosis, or any other medical conditions
  • Are pregnant, breastfeeding, and/or plan to become pregnant or breastfeed. It is not known if Orenitram will harm your unborn baby or if Orenitram passes into your breast milk. You and your healthcare provider should decide if you will take Orenitram or breastfeed. You should not do both

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start or stop any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains the same ingredient, treprostinil. Know the medicines you take. Keep a list of them and the dose you take to show to your healthcare provider and pharmacist when you get a new medicine.

Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider. Stopping Orenitram suddenly may cause worsening of your PAH symptoms. If you miss two or more doses of Orenitram, call your healthcare provider. If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.

If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. Take Orenitram with food.

Orenitram can cause serious side effects, including an increased risk of bleeding. This risk could be increased if you are taking blood thinners such as warfarin.

The most common side effects of Orenitram include headache, diarrhea, nausea and flushing. These are not all of the possible side effects of Orenitram. Tell your doctor about any side effects that bother you, get worse over time, or do not go away.

Indication

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram may improve your ability to exercise. It is not known if Orenitram is safe and effective in children under 18 years of age.

OREISIdtcJAN16

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

Please see Full Prescribing Information and Patient Information for Orenitram.

For additional information about Orenitram, call 1-877-UNITHER (1-877-864-8437).

This information is provided for educational purposes only and is not intended as treatment advice. Consult your healthcare provider for treatment advice.