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PAH Treatment
What is Orenitram? Oral delivery Side effects Patient Support Program

Open up possibilities with Orenitram

What is Orenitram?

Orenitram is an oral prostacyclin-class medicine that has been shown to help slow down the progression of PAH. It also helps improve exercise ability and decrease the symptoms of PAH. With Orenitram, there is information available for your healthcare team about how patients stable on pump therapy (treprostinil) transitioned to oral therapy. It is not known if Orenitram is safe and effective in children under 18 years of age.

Similar medicine as in a pump, but in a tablet

Orenitram is the only pill that gives you the same type of medicine (active ingredient) that is available in pump therapy. In a small study, patients in the hospital stable on pump therapy (treprostinil) successfully switched to Orenitram while maintaining their 6-minute walk distance and right heart catheterization results.

An open-label, uncontrolled (no placebo) study of 33 hospitalized patients with PAH.

Orenitram may help you reach your goals

Because Orenitram is an oral option, you may enjoy activities like being in the pool or taking a bath. Adding Orenitram has been shown to improve many measures of PAH symptoms and function, including:

If you have been diagnosed recently or have had PAH for some time, Orenitram may be right for you.

Doctor Discussion Guide

The Doctor Discussion Guide provides questions and discussion topics to help guide the conversation with your healthcare provider to determine if Orenitram may fit into your treatment plan.

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How does Orenitram work?

If you have PAH, your body may not produce enough of a natural substance called prostacyclin. Orenitram mimics some of the effects of the natural prostacyclin that your body lacks. This can help open up blood vessels, making it easier for your heart to pump blood through your lungs.

Dosing that fits your schedule

Your doctor will prescribe Orenitram to be taken either twice or 3 times each day. With 5 different dose strengths available, your healthcare provider is able to prescribe Orenitram according to your treatment needs. Learn more about taking Orenitram.

You may experience side effects when taking Orenitram

The most common side effects of Orenitram include

There are other possible side effects of Orenitram. Tell your healthcare provider about any side effects that bother you, get worse over time, or do not go away.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

Daily Treatment Diary

The Daily Treatment Diary can help you keep track of how you are feeling each day of treatment. You can also write down important notes that you may want to discuss with your healthcare provider.

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Support during your treatment

In addition to support from your healthcare provider, Orenitram patients can receive support from Specialty Pharmacies and may be eligible for various programs offered by United Therapeutics, the company that makes Orenitram.

Orenitram Support
Is Available

Explore support available, from in-home training to telephone support, as well as educational resources or connecting with a PEER Mentor.

Learn More

Next: How to take Orenitram

Important Safety Information for Orenitram

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

How should I take Orenitram?

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider. Please see Full Prescribing Information and Patient Information at www.orenitram.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).

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IMPORTANT SAFETY INFORMATION FOR ORENITRAM

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Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

  • If you have liver problems or diverticulosis.
  • If you are pregnant, breastfeeding, and/or plan to become pregnant or breastfeed. It is not known if Orenitram will harm your unborn baby or if Orenitram passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with Orenitram.
  • About all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Orenitram and other medicines may affect each other causing side effects. Do not start any new medicine until you check with your healthcare provider. Especially tell your healthcare provider if you take another medicine that contains treprostinil, such as Remodulin® or Tyvaso®.

How should I take Orenitram?

  • Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • Orenitram is usually taken 3 times a day (about every 8 hours) or 2 times a day (about every 12 hours). Your healthcare provider will tell you how often you should take Orenitram. If you have side effects, your healthcare provider may tell you to change your dose or when you take Orenitram. Take Orenitram with food.
  • Swallow Orenitram tablets whole. Do not split, chew, crush, or break your Orenitram tablets. Do not take Orenitram tablets that are damaged or broken. If Orenitram tablets are not taken whole, they may release too much medicine at one time. This can lead to side effects.
  • If you miss your dose of Orenitram, take the missed dose as soon as possible with food.
  • If you miss 2 or more doses of Orenitram, call your healthcare provider to see if you need to change your dose.
  • If you take too much Orenitram, call your healthcare provider or go to the nearest hospital emergency room right away.
  • You may see the tablet shell in your stools (bowel movements). This is usually normal. The tablet shell is not digested. If you have diverticulosis, the tablet shell may get stuck in a blind pouch or diverticulum in your intestine.

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

  • Stopping Orenitram suddenly may cause worsening of your PAH symptoms. Do not change your dose or suddenly stop taking Orenitram without first talking to your healthcare provider.
  • The most common side effects of Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in arms, legs, and jaw. These are not all of the possible side effects of Orenitram. Tell your healthcare provider if you have any side effect that bothers you or does not go away.
  • Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider. Please see Full Prescribing Information and Patient Information at www.orenitram.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).

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