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Tips for Managing Possible Side Effects

Plan ahead to help address possible side effects

Orenitram may cause side effects. Because of the way Orenitram works, it’s possible you may experience side effects before you see the benefits of therapy. Being prepared can help you stay on track with therapy—and give you the opportunity to do more and help control your PAH.

Your healthcare provider will talk to you about potential side effects so you can plan ahead to help address them.

  • The most common side effects with Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in the arms, legs, and jaw

Your healthcare provider may recommend general tips for side effect management

In addition to taking Orenitram exactly as instructed, for example, 3 times a day, approximately every 8 hours with food, your healthcare provider may recommend some of the options listed below to help manage possible side effects.

Headache

  • Acetaminophen
  • Ibuprofen

Nausea and Vomiting

  • Take with food
  • Anti-nausea and anti-vomiting medicine

Diarrhea

  • Add fiber to your diet
  • Anti-diarrhea medicine

United Therapeutics does not provide medical advice. Your healthcare provider will help you develop a plan to manage your side effects.

Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.

Daily treatment journal and tracker

ORENITRAM side effects tracker

Writing down how you are feeling each day may help you manage your treatment and keep track of things you want to discuss with your healthcare provider.

See PDFDownload Now

It is important to talk to your healthcare provider about side effects you experience so you can get advice on how to help manage them.

“Before I started Orenitram, I noticed that I was short of breath. Now, I do see a big difference.”

—An Orenitram patient
PAH=pulmonary arterial hypertension.

IMPORTANT SAFETY INFORMATION FOR ORENITRAM

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

How should I take Orenitram?

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider.

Please see Full Prescribing Information and Patient Information at www.orenitram.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).

OREISIconOCT19

IMPORTANT SAFETY INFORMATION FOR ORENITRAM

Who should not take Orenitram?

Do not take Orenitram if you have severe liver problems.

What should I tell my healthcare provider before taking Orenitram?

Tell your healthcare provider:

How should I take Orenitram?

What are the possible side effects of Orenitram?

Orenitram can cause serious side effects, including worsening of PAH symptoms.

What is Orenitram?

Orenitram is a prescription medicine used to treat pulmonary arterial hypertension (PAH) which is high blood pressure in the arteries of your lungs. Orenitram can help slow down the progression of your disease and improve your ability to exercise. It is not known if Orenitram is safe and effective in children.

The risk information provided here is not comprehensive. To learn more about Orenitram, talk with your healthcare provider.

Please see Full Prescribing Information and Patient Information at www.orenitram.com or call Customer Service at 1-877-UNITHER (1-877-864-8437).

OREISIconOCT19