Tips for Managing Possible Side Effects
Plan ahead to help address possible side effects
Orenitram may cause side effects. Because of the way Orenitram works, it’s possible you may experience side effects before you see the benefits of therapy. Being prepared can help you stay on track with therapy—and give you the opportunity to do more and help control your PAH.
Your healthcare provider will talk to you about potential side effects so you can plan ahead to help address them.
- The most common side effects with Orenitram include headache, diarrhea, nausea, vomiting, flushing, and pain in the arms, legs, and jaw
Your healthcare provider may recommend general tips for side effect management
In addition to taking Orenitram exactly as instructed, for example, 3 times a day, approximately every 8 hours with food, your healthcare provider may recommend some of the options listed below to help manage possible side effects.
Headache
- Acetaminophen
- Ibuprofen
Nausea and Vomiting
- Take with food
- Anti-nausea and anti-vomiting medicine
Diarrhea
- Add fiber to your diet
- Anti-diarrhea medicine
United Therapeutics does not provide medical advice. Your healthcare provider will help you develop a plan to manage your side effects.
Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at www.fda.gov/MedWatch or call 1-800-FDA-1088.
Daily treatment journal and tracker

Writing down how you are feeling each day may help you manage your treatment and keep track of things you want to discuss with your healthcare provider.
See PDFDownload NowIt is important to talk to your healthcare provider about side effects you experience so you can get advice on how to help manage them.
“Before I started Orenitram, I noticed that I was short of breath. Now, I do see a big difference.”
